Association between Serotonin-Related Polymorphisms in 5HT2A, TPH1, TPH2 Genes and Bipolar Disorder in Korean Population
نویسندگان
چکیده
منابع مشابه
Association between Serotonin-Related Polymorphisms in 5HT2A, TPH1, TPH2 Genes and Bipolar Disorder in Korean Population
OBJECTIVE The aim of the present study was to examine the association between serotonin-related gene polymorphisms and bipolar disorder in the Korean population. In addition, we sought to explore the relationship between the clinical characteristics of bipolar patients and serotonin-related gene polymorphisms. METHODS Inpatients with bipolar disorder (n=103) and control subjects (n=86) were g...
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Tryptophan catabolites pathway disorders are observed in patients with depression. Moreover, single nucleotide polymorphisms of tryptophan hydroxylase genes may modulate the risk of depression occurrence. The objective of our study was to confirm the association between the presence of polymorphic variants of TPH1 and TPH2 genes, and the development of depressive disorders. Six polymorphisms we...
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INTRODUCTION Numerous association studies of candidate genes studies with major depressive disorder (MDD) have been conducted for many years; however, the evidence of association between genes and the risk of developing MDD still remains inconclusive. In this study, we aimed to investigate the association between the tryptophan hydroxylase 2 (TPH2) gene and MDD in three ethnic groups (Malay, Ch...
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In this study, we investigated the association between tryptophan hydroxylase-1 (TPH1 ) (218A>C), tryptophan hydroxylase-2 ( TPH2 ) (1463G>A) and serotonin carrier family 6, member 4 (SLC6A4) [long (L) vs. short (S)] gene polymorphisms with post-partum depression (PPD) in women from Jordan. A total of 370 postpartum (130 depressed and 240 non depressed) women volunteered for the study. Genotypi...
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ژورنال
عنوان ژورنال: Psychiatry Investigation
سال: 2010
ISSN: 1738-3684
DOI: 10.4306/pi.2010.7.1.60